Publications

β-peptide bundles: Design. Build. Analyze. Biosynthesize. P.S. Wang & A. Schepartz, Chem. Commun. 2016, 52, 7420-7432. DOI: 10.1039/c6cc01546h

Rotamer-restricted fluorogenicity of the bis-arsenical ReAsH. A.S. Walker, P.R. Rablen, & A. Schepartz, J. Am. Chem. Soc. 2016, epub ahead of print. DOI: 10.1021/jacs.6b03422

In vivo biosynthesis of a ß-amino acid-containing protein. C.M. Czekster, W.E. Robertson, A.S. Walker, D. Söll, & A. Schepartz, J. Am. Chem. Soc. 2016, 138, 5194-5197. DOI: 10.1021/jacs.6b01023

Aqueous glycosylation of unprotected sucrose employing glycosyl fluorides in the presence of calcium ion and trimethylamine. G. Pelletier, A. Zwicker, C. Allen, A. Schepartz, & S. Miller, J. Am. Chem. Soc. 2016, 138, 3175-3182. DOI: 10.1021/jacs.5b13384

Two-colour live-cell nanoscale imaging of intracellular targets. F. Bottanelli, E.B. Kromann, E.S. Allgeyer, R.S. Erdmann, S.W. Baguley, G. Sirinskis, A. Schepartz, D. Baddeley, D.K. Toomre, J.E. Rothman, & J. Bewersdorf. Nat. Commun. 2016, 7, 1-5. DOI: 10.1038/ncomms10778

Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo. M. Li, Y. Tao, Y. Shu, J.R. LaRochelle, A. Steinauer, D. Thompson, A. Schepartz, Z.-Y. Chen, & D. Liu, J. Am. Chem. Soc. 2015, 137, 14084-93. DOI: 10.1021/jacs.5b05694

Improved carbohydrate recognition in water with an electrostatically enhanced β-peptide bundle. M.S. Melicher, A.S. Walker, J. Shen, S.J. Miller, & A. Schepartz, Org. Letts. 2015, 17, 4718-21. DOI: 10.102/acs.orglett.5b02187

Growth factor identity is encoded by discrete coiled-coil rotamers in the EGFR juxtamembrane region. A. doerner, R. Scheck, & A. Schepartz, Chem. Biol. 2015, 22, 776-784. DOI: 10.1016/j.chembiol.2015.05.008

Structural differences between wild-type and double mutant EGFR modulated by third-generation kinase inhibitors. M.A. Lowder, A.E. Doerner, & A. Schepartz, J. Am. Chem. Soc. 2015, 137, 6456-9. DOI: 10.1021/jacs.5b02326

Fluorescence correlation spectroscopy reveals highly efficient cytosolic delivery of certain penta-arg proteins and stapled peptides.  J.R. LaRochelle, G.B. Cobb, A. Steinauer, E. Rhoades, & A. Schepartz, J. Am. Chem. Soc. 2015, 137, 2536-41. DOI: 10.1021/ja510391n

Positive allostery in metal ion binding by a cooperatively folded β-peptide bundle. J.P. Miller, M.S. Melicher, & A. SchepartzJ. Am. Chem. Soc. 2014, 136, 14726-9. DOI: 10.1021/ja508872q

Influence of macrocyclization on allosteric, juxtamembrane-derived, stapled peptide inhibitors of EGFR. J.K. Sinclair & A. Schepartz, Org. Lett. 2014, 16, 4916-9. DOI: 10.1021/ol502426b

Inhibiting epidermal growth factor receptor at a distance. J.K. Sinclair, E.V. Denton, & A. Schepartz, J. Am. Chem. Soc. 2014, 136, 11232-5. DOI: 10.1021/ja504076t

Interactions of AsCy3 with cysteine-rich peptides. S.C. Alexander & A. Schepartz, Org. Lett. 2014, 16, 3824-3827. DOI: 10.1021/ol501721j

Hochaufgelöste Visualisierung des Golgi-Apparats in lebenden Zellen mit einem bioorthogonalen Ceramid.  R.S. Erdmann, H. Takakura, A.D. Thompson, F. Rivera-Molina, E.S. Allgeyer, J. Bewersdorf, D.K. Toomre, & A. SchepartzAngew. Chem. Weinheim. Bergstr. Ger. 2014, 126, 10407-12. DOI: 10.1002/ange.201403349

Super-resolution imaging of the golgi in live cells with a bio-orthogonal ceramide probe. R.S. Erdmann, H. Takakura, A.D. Thompson, F. Rivera-Molina, E.S. Allgeyer, J. Bewersdorf, D.K. Toomre, & A. Schepartz, Angew. Chem. Int. Ed. Engl. 2014, 53, 10242-6. DOI: 10.1002/anie.201403349. Highlight: Chosen as a “Hot Paper”.

Chemistry and the BRAIN initiative.  A.M. Andrews, A. Schepartz, J.V. Sweedler, & P.S. Weiss, J. Am. Chem. Soc. 2014, 136, 1-2. DOI: 10.1021/ja4118347

Design and high-resolution structure of a ß3-peptide bundle catalyst. P.S.P. Wang, J.B. Nguyen, & A. Schepartz, J. Am. Chem. Soc. 2014, 136, 6810-6813. DOI: 10.1021/ja5013849

Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics. J.M. Holub, J.R. LaRochelle, J.S. Appelbaum, & A. Schepartz, Biochemistry 2013, 52, 9036-9046. DOI: 10.1021/bi401069g

Combined lewis acid and bronstead acid-mediated reactivity of glycosyl trichloroacetimidate donors. N.D. Gould, C.L. Allen, B.C. Nam, A. Schepartz, & S.J. Miller, Carbohydr. Res. 2013, 382, 36-42. DOI: 10.1016/j.carres.2013.09.011

A β-peptide agonist of the GLP-1 receptor, a class B GPCR. E.V. Denton, C.J. Craig, R.L. Pongratz, J.S. Appelbaum, A.E. Doerner, A. Narayanan, G.I. Shulman, G.W. Cline, & A. Schepartz, Org. Lett. 2013, 15, 5318-5321. DOI: 10.1021/ol402568j

A β-boronopeptide bundle of known structure as a vehicle for polyol recognition. M.S. Melicher, J. Chu, A.S. Walker, S.J. Miller, R.H.G. Baxter, & A. Schepartz, Org. Lett. 2013, 15, 5048-5051. DOI: 10.1021/ol402381n

Remodeling a ß-peptide bundle.  M.A. Molski, J.L. Goodman, F-C. Chou, D. Baker, R. Das, & A. Schepartz, RSC Chem. Sci. 2013, 4, 319-324. DOI: 10.1039/C2SC21117C

Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation. R.A. Scheck, M.A. Lowder, J.S. Appelbaum, & A. Schepartz, ACS Chem. Bio. 2012, 7, 1367-1376. DOI: 10.1021/cb300216f

Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm. J.S. Appelbaum, J.M. LaRochelle, B.A. Smith, D.M. Balkin, J.M. Holub, & A. Schepartz, Chem. Bio. 2012, 19, 819-830. DOI: 10.1016/j.chembiol.2012.05.022

Rewiring kinase specificity with a synthetic adaptor protein. E.M. Hobert & A. Schepartz, J. Am. Chem. Soc. 2012, 134, 3976-3978. DOI: 10.1021/ja211089v Read the Highlight in Angew. Chem.!

Relationship between side-chain branching and stoichiometry in ß3-peptide bundles. P.S. Wang, C.J. Craig, & A. Schepartz, Tetrahedron 2012, 68, 4342-4345. DOI: 10.1016/j.tet.2012.03.079

Visualizing protein partnerships in living cells and organisms. M.A. Lowder, J.S. Appelbaum, E.M. Hobert, & A. Schepartz, Curr. Opin. Chem. Biol. 2011, 15, 781-788. DOI: 10.1016/j.cbpa.2011.10.024

Molecular imaging: sine labore nihil. A. Schepartz & R.L. Gonzalez Jr., Curr. Opin. Chem. Biol. 2011, 15, 749-751. DOI: 10.1016/j.cbpa.2011.10.001

Surveying protein structure and function using bis-arsenical small molecules. R.A. Scheck & A. Schepartz, Acc. Chem. Res. 2011, 44, 654-665. Download PDF

Enhancing ß3-peptide bundle stability by design. C.J. Craig, J.L. Goodman, & A. Schepartz, ChemBioChem 2011, 12, 1035-1038. Download PDF

Direct visualization of protein association in living cells with complex-edited electron microscopy. R.J. Dexter & A. Schepartz, Angew. Chem. 2010, 49, 7952-7954. Download PDF

Visualizing tyrosine kinase activity with bipartite tetracysteine display. S. Ray-Saha & A. Schepartz, ChemBioChem. 2010, 11, 2089-2091. Download PDF

ß-Peptide bundles with fluorous cores. M.A. Molski, J.L. Goodman, C.J. Craig, H. Meng, K. Kumar, & A. Schepartz, J. Am. Chem. Soc. 2010, 132, 3658-3659. Download PDF

Bridged ß3-peptide inhibitors of p53-hDM2 complexation: Correlation between affinity and cell permeability. A.D. Bautista, J.S. Appelbaum, C.J. Craig, J. Michel, & A. Schepartz, J. Am. Chem. Soc. 2010, 132, 2904-2906. Download PDF

Bipartite tetracysteine display requires site flexibility for ReAsH coordination. J.L. Goodman, D.B. Fried, & A. Schepartz, ChemBioChem 2009, 10, 1644-1647. Download PDF

In silico improvement of ß3-peptide inhibitors of p53·hDM2 and p53·hDMX. J. Michel, E.A. Harker, J. Tirado-Rives, W. Jorgensen, & A. Schepartz, J. Am. Chem. Soc. 2009, 131, 6356-6357. Download PDF Read the Highlight in Nature Chemistry!

Identification of a ß(3)-peptide HIV fusion inhibitor with improved potency in live cells. A.D. Bautista, O.M. Stephens, L. Wang, R.A. Domaoal, K.S. Anderson, & A. Schepartz, Bioorg. Med. Chem. Lett. 2009, 19, 3736-3738. Download PDF

Cell-permeable ß-peptide inhibitors of p53/hDM2 complexation. E.A. Harker & A. Schepartz, ChemBioChem 2009, 10, 990-993. Download PDF

ß-peptides with improved affinity for hDM2 and hDMX. E.A. Harker, D.S.
Daniels, D.A. Guarracino, & A. Schepartz, Bioorg. Med. Chem. 2009, 17, 2038-2046. Download PDF

Selective recognition of protein tetraserine motifs with a cell-permeable, pro-fluorescent bis-boronic acid. T.L. Halo, J. Appelbaum, E.M. Hobert, D.M. Balkin, & A. Schepartz, J. Am. Chem. Soc. 2009, 131, 438-439. Download PDF Read the Review at Faculty1000!

Tetrameric ß(3)-peptide bundles. J.L. Goodman, M.A. Molski, J. Qui, & A. Schepartz, ChembioChem 2008, 9, 1576-1578. Download PDF

Minimally cationic cell-permeable miniature proteins via alpha-helical arginine display. B. Smith, D.S. Daniels, A. Coplin, G. Jordan, L. McGregor, & A. Schepartz, J. Am. Chem. Soc. 2008, 130, 2948-2949. Download PDF

Toward ß-amino acid proteins: design, synthesis, and characterization of a fifteen kilodalton ß-peptide tetramer. E.J. Petersson & A. Schepartz, J. Am. Chem. Soc. 2008, 130, 821-823. Download PDF

Intrinsically cell-permeable miniature proteins based on a minimal cationic PPll motif. D.S. Daniels & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 14578-14579. Download PDF Check out the Commentary in C&E News!

Surveying polypeptide and protein domain conformation and association with FIAsH and ReAsH. N.W. Luedtke, R.J. Dexter, D.B. Fried, & A. Schepartz, Nat. Chem. Biol. 2007, 3, 779-784. Download PDF Read the highlight in Science! Read the highlight in Nature Methods!

Biophysical and structural characterizaion of a robust octameric ß-peptide bundle. J.L. Goodman, E.J. Petersson, D.S. Daniels, J.X. Qiu, & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 14746-14751. Download PDF

Sophistication of foldamer form and function in vitro and in vivo. A.D. Bautista, C.J. Craig, E.A. Harker, & A. Schepartz, Curr. Op. Chem. Biol. 2007, 11, 685-692. Download PDF

Miniature protein ligands for EVH1 domains: Interplay between affinity, specificity, and cell motility. J.H. Holtzman, K. Woronowicz, D. Golemi-Kotra, & A. Schepartz, Biochemistry 2007, 46, 13541-13553. Download PDF Chosen as Hot Article!

Engineering a monomeric miniature protein. A.M. Hodges & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 11024-11025. Download PDF

Biophysical characterization of a ß-peptide bundle: Comparison to natural proteins. E.J. Petersson, C.J. Craig, D.S. Daniels, J.X. Qiu, & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 5344-5345. Download PDF

High resolution structure of a ß-peptide bundle. D.S. Daniels, E.J. Petersson, J.X. Qiu, & A. Schepartz, J. Am. Chem. Soc. 2007, 129, 1532-1533. Download PDF Read the press release! Read the first Highlight in C&E News! Read the second Highlight in C&E News! Read the Review at Faculty1000!

Encodable activators of Src family kinases. C.D. Zellefrow, J.S. Griffiths, S. Saha, A.M. Hodges, J.L. Goodman, J. Paulk, J.A. Kritzer, & A. Schepartz, J. Am. Chem. Soc. 2006, 128, 16506-16507. Download PDF

Toward ß-amino acid proteins: A cooperatively folded ß-peptide quaternary structure. J.X. Qiu, E.J. Petersson, E.E. Matthews, & A. Schepartz, J. Am. Chem. Soc. 2006, 128, 11338-11339. Download PDF

Relationship between salt-bridge identity and 14-helix stability of ß3-peptides in aqueous buffer. D.A. Guarracino, H.R. Chiang, T.N. Banks, J.D. Lear, M.E. Hodsdon, & A. Schepartz, Org Lett. 2006, 8, 807-810. Download PDF

Miniature protein inhibitors of the p53-hDM2 interaction. J.A. Kritzer, R. Zutshi, M. Cheah, F.A. Ran, R. Webman, T.M. Wongjirad, & A. Schepartz, ChemBioChem. 2006, 7, 29-31. Download PDF

A rapid library screen for tailoring ß-peptide structure and function. J.A. Kritzer, N.W. Luedtke, E.A. Harker, & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 14584-14585. Download PDF

Lanthanide-mediated phosphoester hydrolysis and phosphate elimination from phosphopeptides. N.W. Luedtke & A. Schepartz, Chem. Comm. 2005, 43, 5426-5428. Download PDF

Inhibiting HIV fusion with a ß-Peptide foldamer. O.M. Stephens, S. Kim, B.D. Welch, M.E. Hodsdon, M.S. Kay, & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 13126-13127. Download PDF

Relationship between side chain structure and 14-helix stability of ß3-peptides in water. J.A. Kritzer, J. Tirado-Rives, S.A. Hart, J.D. Lear, W.L. Jorgensen, & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 167-178. Download PDF

Paralog-selective ligands for Bcl-2 proteins. A.C. Gemperli, S.E. Rutledge, A. Maranda & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 1596-1597. Download PDF

Binding mode and transcriptional activation potential of high affinity ligands for the CBP KIX domain. H.M. Volkman, S.E. Rutledge, & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 4649-4658. Download PDF

ß-peptides as inhibitors of protein-protein interactions. J.A. Kritzer, O.M. Stephens, D.A. Guarracino, S.K. Reznik, & A. Schepartz, Bio. Med. Chem. 2005, 13, 11-16. Download PDF Awarded "Bioorganic Medicinal Chemistry Most Cited Paper 2003-2006"!

Solution structure of a ß-peptide ligand for hDM2. J.A. Kritzer, M.E. Hodsdon & A. Schepartz, J. Am. Chem. Soc. 2005, 127, 4118-4119. Download PDF

Relationship between folding and function in a sequence-specific miniature DNA-binding protein. L. Yang & A. Schepartz, Biochemistry 2005, 44, 7469-7478. Download PDF

Increasing the kinase specificity of K252a by protein surface recognition. T.L. Schneider, R.S. Mathew, K.P. Rice, K. Tamaki, J.L. Wood & A. Schepartz, Org. Lett. 2005, 7, 1695-1698. Download PDF

Helical ß-peptide inhibitors of the p53-hDM2 interaction. J.A. Kritzer, J.D. Lear, M.E. Hodsdon & A. Schepartz, J. Am. Chem. Soc. 2004, 126, 9468-9469. Download PDF

High affinity, paralog-specific recognition of the Mena EVH1 domain by a miniature protein. D. Golemi-Kotra, R. Mahaffy, M.J. Footer, J.H. Holtzman, T.D. Pollard, J.A. Theriot & A. Schepartz, J. Am. Chem. Soc. 2004, 126, 4-5. Download PDF

Molecular recognition of protein surfaces: High affinity ligands for the CBP KIX domain. S.E. Rutledge, H.M. Volkman & A. Schepartz, J. Am. Chem. Soc. 2003, 125, 14336. Download PDF

Helix macrodipole control of ß3-peptide 14-helix stability in water. S.A. Hart, A.B.F. Bahadoor, E.E. Matthews, X.J. Qiu, & A. Schepartz, J. Am. Chem. Soc. 2003, 125, 4022. Download PDF

Miniature Homeodomains: High specificity without an N-terminal arm. J.K. Montclare & A. Schepartz, J. Am. Chem. Soc. 2003, 125, 3416. Download PDF

A View to a Kill: Ligands for Bcl-2 family proteins. S.E. Rutledge, J.W. Chin & A. Schepartz, Curr. Op. Chem. Biol. 2002, 6, 479-485. Download PDF

Gal4-VP16 and Gal4-AH increase the orientational and axial specificity of TATA box recognition by TBP. A.R. Kays & A. Schepartz, Biochemistry 2002, 41, 3147-3155. Download PDF

Electrostatic control of half-site spacing preferences by the cyclic AMP response element binding protein CREB. J. K. Montclare, L. S. Sloan & A. Schepartz, Nucl. Acids Res. 2001, 29, 3311-3319. Download PDF

Design and evolution of a miniature Bcl-2 binding protein. J.W. Chin & A. Schepartz, Angew. Chem. Int. Ed. Eng. 2001, 40, 3806-3809. Download PDF

Effects of nucleic acids and polyanions on dimer formation and DNA binding by dimeric transcription factors. J.J. Kohler & A. Schepartz, Bioorg. Med. Chem. 2001, 9, 2435-2443. Download PDF

Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display. J.W. Chin, R.M. Grotzfeld, M.A. Fabian & A. Schepartz, Bioorg. Med. Chem. Lett. 2001, 11, 1501-1505. Download PDF

Hepatitis B virus protein pX enhances monomer assembly pathway of bZIP•DNA complexes. T.L. Schneider & A. Schepartz, Biochemistry 2001, 40, 2835-2843. Download PDF

A Roller Coaster Ride of Thrills. A. Schepartz, Chem. Eng. News 2001, 125th Anniversary Issue. Download PDF

Kinetic preference for oriented DNA binding by the yeast TATA-binding protein TBP. Y. Liu & A. Schepartz, Biochemistry 2001, 40, 6257-6266. Download PDF

Kinetic studies of Fos•Jun•DNA complex formation: DNA binding prior to dimerization. J.J. Kohler & A. Schepartz, Biochemistry 2001, 40, 130-142. Download PDF

Concerted evolution of structure and function in a miniature protein. J.W. Chin & A. Schepartz, J. Am. Chem. Soc. 2001, 123, 2929-2930. Download PDF

Hepatitis B virus X protein activates transcription by bypassing CREB phosphorylation, not by stabilizing bZIP-DNA complexes. M.K. Pflum, D. Hall, T. L. Schneider, & A. Schepartz, Biochemistry 2001, 40, 693-703. Download PDF

Virtually unidirectional binding of TBP to the AdMLP TATA box within quaternary complex with TFIIA and TFIIB. A.R. Kays & A. Schepartz, Chem. Biol. 2000, 7, 601-610. Download PDF

Gene Regulation: Protein escorts to the transcription ball. J.W. Chin, J.J. Kohler, T.L. Schneider & A. Schepartz, Curr. Biol. 1999, 9, R929-R932. Download PDF

DNA specificity enhanced by sequential binding of protein monomers. J.J. Kohler, S.J. Metallo, T.L. Schneider & A. Schepartz, Proc. Natl. Acad. Sci. USA 1999, 96, 11735-11739. Download PDF

Highly specific DNA recognition by a designed, miniature protein. N.J. Zondlo & A. Schepartz, J. Am. Chem. Soc. 1999, 121, 6938-6939. Download PDF

Polarity of transcription on Pol II and archaeal promoters: where is the "one-way sign" and how is it read? F. T. Tsai, O. Littlefield, P. F. Kosa, J. M. Cox, A. Schepartz & P.B. Sigler, Cold Spring Harb. Symp. Quant. Biol. 1998, 63, 53-61.

At the chemistry-biology interface. A. Schepartz & P.S. Kim, Curr. Op. Chem. Biol. 1998, 2, 9-10. Download PDF

Preinitiation complex assembly: Potentially a bumpy path. J.M. Cox, A.R. Kays, J.F. Sanchez & A. Schepartz, Curr. Op. Chem. Biol. 1998, 2, 11-17. Download PDF

Sequence determinants of the intrinsic bend in the cyclic AMP response element. L.S. Sloan & A. Schepartz, Biochemistry 1998, 37, 7113-7118. Download PDF

Mechanism of DNA binding enhancement by the Hepatitis B virus protein X. C.R. Palmer, L.D. Gegnas, A. Schepartz, Biochemistry 1997, 36, 15349-15355. Download PDF

Induced DNA bending by the Zn2Cys6 binuclear cluster protein PUT3. P. Hoffmann & A. Schepartz, Bio. Med. Chem. Lett. 1997, 7, 2049-2054. Download PDF

Kinetics and mechanism of RNA binding by triplex tethered oligonucleotide probes. A.C. Moses & A. Schepartz, J. Am. Chem. Soc. 1997, 119, 11591-11597. Download PDF

The role of a basic amino acid cluster in target site selection and nonspecific binding of bZIP peptides to DNA. S.J. Metallo, D.N. Paolella, & A. Schepartz, Nucl. Acids Res. 1997, 25, 2967-2972. Download PDF

Bidirectional binding of the TATA box binding protein to the TATA box. J.M. Cox, M.H. Hayward, J.F. Sanchez, L.D. Gegnas, S. van der Zee, J.H. Dennis, P.B. Sigler, & A. Schepartz, Proc. Natl. Acad. Sci. 1997, 94, 13475-13480. Download PDF

Electrostatic mechanism for DNA bending by bZIP proteins. D.N. Paolella, Y. Liu & A. Schepartz, Biochemistry 1997, 36, 10033-10038. Download PDF

Inhibition of Rev•RRE complexation by triplex tethered oligonucleotide probes. A.C. Moses, S.W. Huang & A. Schepartz, Bioorg. Med. Chem. 1997, 5, 1123-1129. Download PDF

Certain bZIP proteins bind DNA sequentially as monomers and dimerize on the DNA. S.J. Metallo & A. Schepartz, Nat. Str. Biol. 1997, 4, 115-117.

Triplex tethered oligonucleotide probes. A.C. Moses & A. Schepartz, J. Am. Chem. Soc. 1996, 118, 10896-10897. Download PDF

Conformation of tax-response elements in the human T-cell leukemia virus type I promoter. J.M. Cox, L.S. Sloan & A. Schepartz, Chemistry & Biology 1995, 2, 819-826.

Studies on the formation of protein•DNA interfaces: DNA specificity and straightening by CREB. M.K. Hamm & A. Schepartz, Bio. Med. Chem. Lett. 1995, 5, 1621-1626. Download PDF

DNA bending and binding by metallo-peptide models of bZIP proteins. C.R. Palmer, L.S. Sloan, J.C. Adrian, Jr., B. Cuenoud, D.N. Paolella & A. Schepartz, J. Am. Chem. Soc. 1995, 117, 8899-8907. Download PDF

Mechanism of DNA binding enhancement by the HTLV-I transactivator tax. A.M. Baranger, C.R. Palmer, M.K. Hamm, H. A. Giebler, A. Brauweiler, J.K. Nyborg, & A. Schepartz, Nature 1995, 376, 606-608. Download PDF

Convenient syntheses of reagents for cleavage mapping experiments. M. H. Hayward, J. C. Adrian, Jr. & A. Schepartz, J. Org. Chem. 1995, 60, 3924-3927. Download PDF

Technical comment: Nonspecific DNA bending and the specificity of protein•DNA interactions. A. Schepartz, Science 1995, 269, 988-989. Download PDF

Peptide models of bZIP proteins: Quantitative analysis of DNA affinity and specificity. S.J. Metallo & A. Schepartz, Tech. Protein Chem. 1995, VI, 385-391.

Mechanistic studies on the formation of bZIP•DNA interfaces: A simple example of supramolecular stereochemistry. D.N. Paolella, C.R. Palmer, S.J. Metallo & A. Schepartz, in Supramolecular Stereochemistry, J. Siegel, Ed. NATO Adv. Ser. 1995, 83-90.

A uniquely modified RNA: Site-specific introduction of a single RNA cleavage agent into the M1 ribozyme. P.L. Richardson, M.L. Gross, R.D. Smith, K.J. Light-Wahl, & A. Schepartz, Bio. Med. Chem. Lett. 1994, 4, 2133-2138. Download PDF

Distribution of labor among CRE-BP1 bZIP segments in the control of DNA affinity and specificity. S.J. Metallo & A. Schepartz, Chem. Biol. 1994, 1, 143-152.

Mapping regions in eukaryotic ribosomes that are accessible to methidiumpropyl- EDTA•Fe(II) and EDTA•Fe(II). H. Han, A. Schepartz, M. Pelligrini & P.B. Dervan, Biochemistry 1994, 33, 9831-9844. Download PDF

DNA targets for certain bZIP proteins distinguished by an intrinsic bend. D.N. Paolella, C.R. Palmer & A. Schepartz, Science 1994, 264, 1130-1133. Download PDF

Selection of structure-specific inhibitors of the HIV rev–rev response element Complex. S.T. Cload & A. Schepartz, J. Am. Chem. Soc. 1994, 116, 437-443. Download PDF

A kinetic and thermodynamic analysis of RNA binding by tethered oligonucleotide probes: Alternative structures and conformational changes. S.T. Cload, P.L. Richardson, Y. Huang & A. Schepartz, J. Am. Chem. Soc. 1993, 115, 5005-5014. Download PDF

Altered specificity of DNA-binding proteins with transition metal dimerization domains. B. Cuenoud & A. Schepartz, Science 1993, 259, 510-513. Download PDF

Design of a metallo-bZIP peptide that discriminates between CRE and AP1 target sites: Selection against AP1. B. Cuenoud & A. Schepartz, Proc. Natl. Acad. Sci. USA 1993, 90, 1154-1159. Download PDF

Protein-cleavage mapping: A new tool for drug discovery and protein folding studies. M. Hayward & A. Schepartz, in Perspectives in Medicinal Chemistry, Testa, B., Kyburz, E., Fuhrer, W.; Giger, R., Eds., Verlag: Basel, 1993, p. 501-512.

Conformation-dependent cleavage of staphylococcal nuclease with a disulfide-linked iron chelate. M. Ermacora, J.M. Delfino, B. Cuenoud, A. Schepartz & R.O. Fox, Proc. Natl. Acad. Sci. USA 1992, 89, 6383-6387. Download PDF

A new strategy for directed protein cleavage. B. Cuenoud, T. Tarasow & A. Schepartz, Tetrahedron Lett. 1992, 33, 895-898. Download PDF

Binding of alkali cations by self-assembling ionophore complexes of Ni(II). M.W. Jones, N. Gupta, A. Schepartz & H. Thorpe, Inorg. Chem. 1992, 31, 1308-1310. Download PDF

A general scheme for incorporating nonnatural functionality into peptides. B. Cuenoud & A. Schepartz, Tetrahedron Lett. 1991, 32, 3325-3328.

Polyether tethered oligonucleotide probes. S.T. Cload & A. Schepartz, J. Am. Chem. Soc. 1991, 113, 6324-6326. Download PDF

Tethered oligonucleotide probes. A strategy for the recognition of structured RNA. P. Richardson & A. Schepartz, J. Am. Chem. Soc. 1991, 113, 5109-5111. Download PDF

Synthesis of alpha-BOC-epsilon-EDTA-lysine tribenzyl ester. An amino acid analog suitable for solid phase peptide synthesis. B. Cuenoud & A. Schepartz, Tetrahedron 1991, 47, 2535- 2542. Download PDF

Site-specific cleavage of the protein calmodulin using a trifluoperazine-based affinity reagent. A. Schepartz & B. Cuenoud, J. Am. Chem. Soc. 1990, 112, 3247-3249. Download PDF

Self-assembling ionophores. A. Schepartz & J.P. McDevitt, J. Am. Chem. Soc. 1989, 111, 5976-5977. Download PDF

On the mechanism of catalysis by the enzyme carboxypeptidase A. R. Breslow & A. Schepartz, Chemistry Letters 1987, 1-4.

Hydrolysis of an amide in a carboxypeptidase model using Co(III) and bifunctional catalysts. A. Schepartz & R. Breslow, J. Am. Chem. Soc. 1987, 109, 1814-1826. Download PDF

Substituent effect on the electrochemical oxidation of arylmethyl anions. 3. Effect of methyl substitution on diarylmethyl anions. S. Bank, A. Schepartz, P. Giammateo, J. Zubieta, J. Org. Chem. 1983, 48, 3548-3564. Download PDF